Senolytic research

Posted on Posted in home1, Senolytic modeling

Overview

We provide a suite of services for the identification and evaluation of senolytic drug compounds, from cell-based assays to animal models and lifespan studies.  Standardized and validated in-house assays are available along with custom or novel analysis techniques.

Capabilities and services

  • Fluorescence-based screens of up to 170,000 compounds (or different quantity of customer provided compounds) for p53/FOXO4 interaction
  • Assay development
  • On target validation in senescence culture models
  • Induction, verification, and quantification of senescence both in vitro and in vivo
  • Assays for targeted apoptosis in senescent cell populations
  • Immunofluorescence imaging and assays for senescence-associated targets
  • qPCR measures of mRNA expression changes in genes of interest
  • Immunoblotting of relevant protein targets
  • Full animal husbandry services
  • Fluorescence and magnetic cell sorting