Careers

Internships

Ichor Therapeutics engages in research projects ranging from laboratory automation, to stem cell biology, animal husbandry, and beyond. Each intern will work with staff researchers to design and complete independent and group projects. Interns are expected to give weekly oral presentations of their research, create a poster at the conclusion of the internship, and if appropriate, publish the results of their experiments.

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Full-time positions

Study Director - Cellular Senescence

Study Director - Cellular Senescence

PAY: $55,000 - $75,000 + Benefits DoE

JOB DESCRIPTION: Ichor Therapeutics is looking for a full-time Study Director to join our team! The successful applicant will have PhD-level training (ABD acceptable) and have experience in designing and executing projects relating to cell culture models. Experience working with primary cell lines, pluripotent stem cells, and/or senescent cells is strongly preferred. Experience working in a GLP environment and involvement in IND submissions is desired but not required. This position will involve the design and execution of research projects as part of an interdisciplinary team, manuscript preparation for peer-reviewed publication, grant writing, and presentations to senior management. This position provides extensive opportunity for promotion and growth within the company.

PROJECT SUMMARY: Antoxerene, a portfolio company of Ichor Therapeutics, is developing first in class small molecule senolytic drug candidates. The successful applicant will develop and validate cell-based and in vivo models of cellular senescence, and work collaboratively to test small molecule leads on diverse senescence pathways.

QUALIFICATIONS:
- PhD in pharmacology, toxicology, cell biology, biochemistry, or a related discipline (ABD acceptable)
- Technical expertise in cellular assays and methodologies (i.e. qPCR, WB, flow cytometry, ELISA, RNA-seq, viability assays)
- Must be able to operate independently and as a part of a team for execution of projects of varying scale

Study Director - Antibody Mimetics

Study Director - Antibody Mimetics

PAY: $55,000 - $75,000 + Benefits DoE

DESCRIPTION: Ichor Therapeutics is looking for a full-time Study Director to join our team! The successful applicant will have PhD-level training (ABD acceptable) and have experience in designing and executing projects relating to monoclonal antibody production and characterization. Experience with protein-protein interaction studies, epitope mapping, immunology, and/or protein engineering is strongly preferred. Experience working in a GLP environment and involvement in IND submissions is desired but not required. This position will involve the design and execution of research projects as part of an interdisciplinary team, manuscript preparation for peer-reviewed publication, grant writing, and presentations to senior management. This position provides extensive opportunity for promotion and growth within the company.

PROJECT SUMMARY: Auctus Biologics, a portfolio company of Ichor Therapeutics, is developing a novel orally bioavailable antibody mimetic scaffold for therapeutic and diagnostic applications. The successful applicant will work collaboratively with the Ichor team to guide the development path for this program through high-throughput mutagenicity screens, candidate selection, and candidate validation in cell-based and in vivo assays.

QUALIFICATIONS:
- PhD in pharmacology, toxicology, immunology, biochemistry, or a related discipline (ABD acceptable)
- Technical expertise in cellular assays and methodologies (i.e. epitope mapping, mutagenicity screens, ADMET/PK/BD)
- Must be able to operate independently and as a part of a team for execution of projects of varying scale

Study Director - Enzyme Therapy/Ophthalmology

Study Director - Enzyme Therapy/Ophthalmology

PAY: $55,000 - $75,000 + Benefits DoE

DESCRIPTION: Ichor Therapeutics is looking for a full-time Study Director to join our team! The successful applicant will have PhD-level training (ABD acceptable) and have experience in designing and executing projects relating to EITHER recombinant enzyme expression, purification, and characterization OR cellular and in vivo ophthalmology models. Experience with lysosomal storage diseases (enzyme therapy development, uptake assays, efficacy models), protein engineering, and/or macular degeneration (OCT, retinal histology, primary explant models) is strongly preferred. Experience working in a GLP environment and involvement in IND submissions is desired but not required. This position will involve the design and execution of research projects as part of an interdisciplinary team, manuscript preparation for peer-reviewed publication, grant writing, and presentations to senior management. This position provides extensive opportunity for promotion and growth within the company.

PROJECT SUMMARY: Lysoclear, a portfolio company of Ichor Therapeutics, is developing an enzyme therapy to remove intracellular lipofuscin that drives the onset and progression of age-related macular degeneration and Stargardt's macular degeneration. The successful applicant will work collaboratively with the Ichor team to guide the development path for this program to validate leads and a drug candidate in cell-based and in vivo assays.

QUALIFICATIONS:
- PhD in pharmacology, toxicology, ophthalmology, biochemistry, biophysics, enzymology or a related discipline (ABD acceptable)
- Technical expertise in methodologies as outlined above
- Must be able to operate independently and as a part of a team for execution of projects of varying scale

Research Scientist - Biochemistry

Research Scientist - Biochemistry

PAY: $48,000 - $65,000 + Benefits DoE

DESCRIPTION: Ichor Therapeutics is looking for a Full-Time biochemist to join our Biochemistry research group. The successful applicant will have PhD-level training in biochemistry or a related discipline (ABD acceptable) and have experience in producing recombinant proteins in yeast, particularly enzymes in Saccharomyces cerevisiae and Pichia pastoris in bioreactors and shaker flasks. Experience with glycobiology and glycoengineering preferred. Applicant will be responsible for  all aspects of protein production and characterization, including vector design, host system selection, expression optimization, prep design and execution, purity assessment, sequence confirmation, structure evaluation, and activity confirmation. Applicant should have experience with FPLC, including affinity, ion exchange, and size exclusion chromatography. The position will require meticulous documentation effective presentation of methods and data both in written and oral formats. The successful candidate will work as part of a 3-4 member department, and will receive extensive opportunities to cross-train in other departments.

QUALIFICATIONS:
- PhD in biochemistry or related field (ABD acceptable)
- Technical expertise in recombinant protein production in yeast, experience with enzymes and glycoengineering preferred
- Experience in assay development and prep design is essential
- Must be able to operate independently and as a part of a team for execution of projects of varying scale

Research Scientist - Cell Biology

Research Scientist - Cell Biology

PAY: $48,000 - $65,000 + Benefits DoE

DESCRIPTION: Ichor Therapeutics is seeking a Cell Biologist with a broad range of experimental and technical expertise to fill an available Scientist position.  The ideal candidate for this position will be highly comfortable working independently to design and perform a broad range of in vitro experiments and assays for internal and external stakeholders.

PhD in biological sciences preferred (ABD acceptable); MS with 3-5+ years of experience considered.

RESPONSIBILITIES:
- Independently design and execute original experiments to support a variety of research projects
- Optimize and/or troubleshoot new and existing processes
- Follow established protocols and SOPs
- Documentation in compliance with GLP standards
- Cooperate and communicate effectively with a small team of skilled technicians and interdepartmental colleagues to complete experiments

DESIRED SKILLS:
- Extensive wet lab and aseptic cell culture experience
- Expertise in designing and performing RT-qPCR assays, mammalian cell transformations, and data analysis and interpretation
- Familiarity with imaging and microscopy techniques
- Broad skills and experience with molecular biology techniques
- Clear and effective communication, including detailed scientific reporting and record keeping

Research Technician - Biochemistry

Research Scientist - Biochemistry

PAY: DoE

DESCRIPTION: Ichor Therapeutics is looking for a full-time technician to join our biochemistry research group. The successful applicant will have BSc or MSc-level training in biochemistry or a related discipline and have experience in producing recombinant proteins. Experience with glycobiology and glycoengineering preferred but not required. Applicant will be responsible for following methods to produce and characterize recombinant proteins, including expression optimization, prep design and execution, purity assessment, sequence confirmation, structure evaluation, and activity confirmation. Applicant should have experience with FPLC, including affinity, ion exchange, and size exclusion chromatography. The position will require meticulous documentation effective presentation of methods and data both in written and oral formats. The successful candidate will work as part of a 3-4 member department, and will receive extensive opportunities to cross-train in other departments.

QUALIFICATIONS:
- BSc or MSc in biochemistry or related field
- Technical expertise in recombinant protein production, experience with enzymes and glycoengineering preferred
- Must be able to operate independently and as a part of a team for execution of projects of varying scale

Licensed Veterinary Technician

Licensed Veterinary Technician

PAY: DOE

QUALIFICATIONS: Must be a licensed veterinary technician in the state of New York. Previous lab animal work preferred but not mandatory. Non-smoker. Must be able to lift 30lbs.

DESCRIPTION: Work includes daily monitoring of the animals, assisting and performing study procedures, quality control of the facility, documentation of procedures, and general maintenance of facility. Must be meticulous and able to work in a clean facility according to SOPs and regulations. Knowledge of Microsoft Office necessary.

Veterinary Assistant

Veterinary Assistant

PAY: DoE

QUALIFICATIONS: High school diploma, college preferred. Previous animal care work necessary. Non-smoker. Must be able to lift 30lbs.

DESCRIPTION: Work includes daily monitoring of animals, ensuring animals have food and water, providing animals with new cages, general maintenance of facility, quality control of the facility, and documentation of procedures. Must be meticulous and able to work in a clean facility according to SOPs and regulations.

Part-time and contract positions

Cage Cleaner

Cage Cleaner

PAY: Please inquire

QUALIFICATIONS: High school diploma. Non-smokers. Must be able to lift 30lbs.

DESCRIPTION: Work includes washing animal cages, preparing animal cages for use, and documenting work performed. Must be meticulous and able to work in a clean facility according to SOPs and regulations. Previous animal related work preferred but not mandatory.